Assessment of Systemic Inflammatory Markers Linked to High-Density Lipoprotein Levels in Patients with Keratoconus: A Retrospective Case-Control Analysis - Summary - MDSpire
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Assessment of Systemic Inflammatory Markers Linked to High-Density Lipoprotein Levels in Patients with Keratoconus: A Retrospective Case-Control Analysis
To evaluate specific systemic inflammatory markers, including MHR, NHR, LHR, NLR, and PHR, in patients with keratoconus and their correlation with corneal topographic parameters.
Key Findings:
Significant difference in mean platelet/high-density lipoprotein ratio (PHR) between keratoconus patients and controls (p = 0.004; 95% CI: [insert CI]).
No significant correlations found between corneal topography indices, best corrected visual acuity (BCVA), and systemic inflammatory markers.
Optimal ROC cutoff value for PHR in keratoconus was 4807 with 74.8% sensitivity and 45.5% specificity.
Interpretation:
The study suggests that PHR may serve as a potential inflammatory marker in keratoconus, although its clinical utility is limited by low specificity, which may hinder its application in practice.
Limitations:
Retrospective design may introduce selection bias, potentially affecting the validity of the findings.
Small sample size may limit generalizability of findings.
Lack of longitudinal data to assess changes over time.
Conclusion:
PHR shows promise as an inflammatory marker in keratoconus, but further studies with larger sample sizes are needed to validate its clinical relevance.
