Response quality of large language models on periprosthetic fractures: A comparative evaluation of ChatGPT, Gemini, and Claude - Summary - MDSpire
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Evaluating the Quality of Responses from Large Language Models on Periprosthetic Fractures: A Comparison of ChatGPT, Gemini, and Claude

  • By

  • Buğra Can

  • Anıl Agar

  • İrfan Arslan

  • September 29, 2026

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Objective:

To compare the accuracy, quality of information, safety, response length, and readability of responses from ChatGPT, Gemini, and Claude regarding periprosthetic fractures.

Approach:
  • Study Design: A question-based paired investigation was conducted using a set of 25 standardized patient questions related to periprosthetic fractures.
  • Question Development: Questions were generated by orthopaedic residents and refined through a two-step reduction process to ensure clarity and relevance.
  • Response Evaluation: Responses from each model were assessed by a blinded expert panel using predefined scoring systems for accuracy and quality.
Key Findings:
  • Large language models can produce fluent text but may also convey inaccurate information.
  • A total of 25 questions were developed to cover key patient concerns and decision points.
Limitations:
  • The single-query design may not fully capture variability in LLM-generated responses.
  • Responses were evaluated in a randomized order, which may affect scoring consistency.

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