To compare the diagnostic performance of different functional imaging modalities for the detection of primary and metastatic phaeochromocytomas and paragangliomas (PPGLs).
Approach:
Study Design: Retrospective, cross-sectional comparative study at a tertiary referral centre from 2012 to 2023.
Participants: 73 patients diagnosed with PPGL, with 38 undergoing triple functional imaging (FDG, Dotatate, mIBG).
Imaging Techniques: Patients underwent 18F-FDG PET CT/MRI, 68Ga-DOTATATE PET/CT, and 123I-mIBG SPECT/CT.
Data Analysis: Detection rates for primary and metastatic disease were compared and correlated with SUVmax, metanephrine profiles, and germline mutations.
Key Findings:
Overall detection rates were positive in 36/38 (94.7%) patients on FDG, 35/38 (92.1%) on Dotatate, and 34/38 (89.5%) on mIBG.
Among patients with metastatic disease, lesion detection was observed in 16/16 (100%) with FDG, 12/13 (92.3%) with Dotatate, and 11/13 (84.6%) with mIBG.
FDG demonstrated 100% detection in patients with SDHB (6/6) and VHL (3/3) mutations.
Interpretation:
Limitations:
Retrospective design may introduce selection bias.
by Norah Alhazzaa, Mohammad M. R. Eddama, Fawziah Alorfi, Teng Teng Chung, Helen Simpson, Srirangalingam Umasuthan, Steve Hurel, Virginia Rozalen-Garcia, Tom Kurzawinski, Simon Wan, Jamshed Bomanji, Mark Gaze, Tarek Ezzat Abdel-Aziz
