Healthy Aging and the Gut Microbiome in People With and Without HIV - Summary - MDSpire

Healthy Aging and the Gut Microbiome in People With and Without HIV

  • By

  • Brandilyn A Peters

  • Xiaonan Xue

  • David B Hanna

  • Yi Wang

  • Zheng Wang

  • Anjali Sharma

  • Michelle Floris-Moore

  • Deborah Konkle-Parker

  • Maria L Alcaide

  • Anandi N Sheth

  • Elizabeth F Topper

  • Kathleen M Weber

  • Phyllis C Tien

  • Daniel Merenstein

  • Elizabeth Vásquez

  • Yue Chen

  • Matthew J Mimiaga

  • Valentina Stosor

  • Todd T Brown

  • Kristine M Erlandson

  • Stephanie M Dillon

  • Noha S Elsayed

  • Mykhaylo Usyk

  • Christopher C Sollecito

  • Robert C Kaplan

  • Robert D Burk

  • Qibin Qi

  • January 22, 2025

  • 0 min

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Objective:

To explore the relationship between aging, gut microbiome diversity, and health outcomes in individuals with and without HIV, emphasizing its significance for public health.

Key Findings:
  • Older age is associated with greater gut microbiome diversity and uniqueness, which may have implications for health outcomes.
  • Specific genera such as Akkermansia and Streptococcus increased with age, while Prevotella and Faecalibacterium decreased, indicating shifts in microbiome composition.
  • An aging-related microbiome score increased with age, independent of demographic and health factors, suggesting a consistent pattern across populations.
  • Age-microbiome associations were stronger in men without HIV compared to those with HIV, highlighting potential differences in microbiome health.
Interpretation:

The gut microbiome undergoes significant changes with aging, which may influence health outcomes, particularly in individuals with HIV, warranting further investigation.

Limitations:
  • The study excluded transgender individuals, potentially limiting generalizability to the broader population.
  • The analysis was observational and cannot establish causation, which may affect the interpretation of the results.
Conclusion:

Age-related changes in the gut microbiome are consistent across sexes and HIV status, with certain microbial taxa linked to healthy aging and frailty, suggesting avenues for future research.

Original Source(s)

Healthy Aging and the Gut Microbiome in People With and Without HIV

  • by Brandilyn A Peters, Xiaonan Xue, David B Hanna, Yi Wang, Zheng Wang, Anjali Sharma, Michelle Floris-Moore, Deborah Konkle-Parker, Maria L Alcaide, Anandi N Sheth, Elizabeth F Topper, Kathleen M Weber, Phyllis C Tien, Daniel Merenstein, Elizabeth Vásquez, Yue Chen, Matthew J Mimiaga, Valentina Stosor, Todd T Brown, Kristine M Erlandson, Stephanie M Dillon, Noha S Elsayed, Mykhaylo Usyk, Christopher C Sollecito, Robert C Kaplan, Robert D Burk, Qibin Qi

  • January 22, 2025

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