Is COVID-19 Associated With an Increased Risk of Subsequent Upper Respiratory Tract Infections in Adults? A Prospective Cohort Study - Summary - MDSpire

Is COVID-19 Associated With an Increased Risk of Subsequent Upper Respiratory Tract Infections in Adults? A Prospective Cohort Study

  • By

  • Fazia Tadount

  • Guy Boivin

  • Yves Longtin

  • Patrice Savard

  • Matthew P Cheng

  • Hélène Decaluwe

  • Gaston De Serres

  • Élise Fortin

  • Caroline Quach

  • September 2, 2025

  • 0 min

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Objective:

To assess if COVID-19 is associated with a higher incidence of upper respiratory tract infections (URTIs) in adults in the months following infection.

Key Findings:
  • No significant difference in URTI incidence was observed following COVID-19 (hazard ratio, 1.03; 95% CI, 0.74–1.43; P = .87), indicating no increased risk.
  • Having at least 1 child <5 years was associated with a 74% increase in the risk for URTI (95% CI, 20%–153%; P = .003).
  • Findings remained consistent in sensitivity analysis.
Interpretation:

The study found no association between COVID-19 and subsequent URTI risk in adults, suggesting that other factors may explain increased URTI incidence.

Limitations:
  • The study was limited to health care workers, which may not represent the general population.
  • Potential recall bias in self-reported symptoms and reliance on electronic surveys.
  • The findings may not be generalizable beyond the specific demographic and geographic context of the study.
Conclusion:

COVID-19 does not appear to increase the risk of subsequent URTIs in adults, and other epidemiological factors may play a significant role in URTI incidence.

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