Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study - Summary - MDSpire

Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study

  • By

  • Jenni Turunen

  • Kaisu Kyrö

  • Janica Virta

  • Marko Suokas

  • Jenni Hekkala

  • Sonja Karikka

  • Anna Kaisanlahti

  • Justus Reunanen

  • Niko Paalanne

  • Mysore V. Tejesvi

  • Terhi Ruuska-Loewald

  • May 28, 2026

  • 0 min

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Objective:

To investigate how maternal factors influence the microbiota-derived extracellular vesicles (EVs) secreted by the maternal microbiota into the amniotic fluid and feces of pregnant women.

Approach:
    Key Findings:
    • Microbiota-derived EVs are distinct from gut microbiota and can cross biological barriers.
    • Maternal factors significantly influence the secretion of microbiota-derived EVs during pregnancy.
    • The study utilized a robust methodology for isolating and characterizing EVs from fecal and amniotic fluid samples.
    Interpretation:

    Limitations:
    • The study was limited to a specific cohort and may not be generalizable to all pregnant populations.
    • Amniotic fluid samples were only collected from women undergoing elective C-sections.
    Conclusion:

Original Source(s)

Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study

  • by Jenni Turunen, Kaisu Kyrö, Janica Virta, Marko Suokas, Jenni Hekkala, Sonja Karikka, Anna Kaisanlahti, Justus Reunanen, Niko Paalanne, Mysore V. Tejesvi, Terhi Ruuska-Loewald

  • May 28, 2026

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