Pericyte loss and endothelial activation define distinct vascular states in cerebral small vessel disease - Summary - MDSpire
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Distinct vascular states in cerebral small vessel disease are marked by pericyte loss and endothelial activation

  • By

  • A. Chagnot

  • D. Jaime Garcia

  • C. McQuaid

  • J. Cholewa-Waclaw

  • K. McDade

  • O. Dando

  • J. M. Wardlaw

  • C. Smith

  • A. Montagne

  • October 13, 2026

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Objective:

To examine how pericyte markers and endothelial activation relate across human brain microvessels with differing neuropathological cSVD severity.

Approach:
  • Tissue: The study included brain sections from 20 cases, sampling Brodmann area 4 and subjacent white matter.
  • Analysis: High-resolution quantitative analyses assessed pericyte and endothelial markers at single-vessel resolution.
Interpretation:

The provided context describes the study rationale and methods but does not report results.

Limitations:
  • The supplied article context ends during the methods section and does not provide study results or a full account of methods.

Original Source(s)

Pericyte loss and endothelial activation define distinct vascular states in cerebral small vessel disease

  • by A. Chagnot, D. Jaime Garcia, C. McQuaid, J. Cholewa-Waclaw, K. McDade, O. Dando, J. M. Wardlaw, C. Smith, A. Montagne

  • October 13, 2026

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