Outcomes Related to Bacterial Co-Infection and Antibiotic Use in Adults Hospitalized With Respiratory Syncytial Virus Compared with Influenza - Summary - MDSpire
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Outcomes Related to Bacterial Co-Infection and Antibiotic Use in Adults Hospitalized With Respiratory Syncytial Virus Compared with Influenza
To evaluate the impact of bacterial co-infections and antibiotic use on clinical outcomes in adults hospitalized with RSV compared to those with influenza A or B, emphasizing the comparative aspect.
Key Findings:
Out of 986 patients, 352 had RSV, 347 had influenza A, and 287 had influenza B, highlighting the distribution of cases.
Bacterial co-infections were found in 23% of RSV, 25% of influenza A, and 28% of influenza B patients, indicating a notable prevalence.
Antibiotic use was common among patients without bacterial co-infection: 77% for RSV, 71% for influenza A, and 75% for influenza B, raising concerns about antibiotic stewardship.
Bacterial co-infection in RSV patients was not associated with increased mortality or adverse clinical outcomes, suggesting a need for reevaluation of treatment protocols.
Early antibiotic treatment was linked to prolonged length of stay but did not improve survival, indicating potential overuse.
Interpretation:
Bacterial co-infections are prevalent among hospitalized patients with RSV and influenza, but they do not appear to significantly impact mortality or clinical outcomes in RSV patients. Antibiotic treatment does not confer survival benefits, suggesting a need for careful consideration in prescribing practices.
Limitations:
Study conducted in two tertiary care hospitals, which may limit generalizability to other settings.
Potential for unmeasured confounding factors affecting outcomes, which could skew results.
Conclusion:
Bacterial co-infections are common in hospitalized adults with RSV and influenza, but they do not correlate with worse clinical outcomes in RSV patients. Antibiotic treatment does not improve survival, highlighting the need for judicious use.
by Kristine L Karlsen, Clara L Clausen, Ragda A S Kahiyah, Aymen Alkarawi, Amanda M Egeskov-Cavling, Noor Hayder, Adin Sejdic, Casper Roed, Jon G Holler, Lene Nielsen, Mads F Eiberg, Omid Rezahosseini, Christian Østergaard, Zitta B Harboe, Thea K Fischer, Birgitte Lindegaard, Thomas Benfield
