Performance evaluation of five major large language models in tuberculosis Q&A systems: A multidimensional assessment of readability, quality, and reliability - Summary - MDSpire

Performance evaluation of five major large language models in tuberculosis Q&A systems: A multidimensional assessment of readability, quality, and reliability

  • By

  • Rong Liu

  • Ying Chen

  • Wenzhuo Zhao

  • Yihuan Cai

  • July 10, 2026

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Objective:

To systematically evaluate the performance of five large language models in common question and answer scenarios related to pulmonary tuberculosis, focusing on readability, quality, and reliability.

Approach:
  • Research Procedure: Twenty frequently asked questions about pulmonary tuberculosis were compiled and entered into five large language models. Their answers were evaluated for readability, reliability, and overall quality.
  • Readability Evaluation: Various readability formulas were used to assess the generated text, including the Automated Readability Index, SMOG, Coleman-Liau Readability Index, and others.
  • Quality Assessment: The Patient-education suitability (C-PEMAT-P) scale and the Global Quality Score (GQS) were utilized to evaluate the reliability of the answers.
Key Findings:
  • The performance of the five large language models varied significantly in terms of readability and quality.
  • Models demonstrated differences in language style, comprehensibility, and accuracy of citations.
  • The study emphasizes the need for evaluating AI-generated health information for patient education.
Interpretation:

The findings suggest that while large language models can provide health information, their variability in quality and readability may affect user understanding and trust.

Limitations:
  • The study did not involve human or animal experiments, which may limit the applicability of findings to real-world scenarios.
  • The absence of an internationally accepted standard for readability assessment may affect the reliability of the results.
Conclusion:

This study establishes a basis for enhancing large language models in health education concerning pulmonary tuberculosis.

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