Case Report: Focal nodular hyperplasia of the liver in an adolescent—a case report and literature review - Summary - MDSpire

Case Report: Focal nodular hyperplasia of the liver in an adolescent—a case report and literature review

  • By

  • Rongchun Xing

  • Yuhong Wen

  • Dan Yu

  • Chongyuan Chen

  • Mingzheng Hu

  • June 16, 2026

  • 0 min

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Objective:

To present a case of adolescent focal nodular hyperplasia (FNH) and review the literature on its clinical findings and management strategies, emphasizing the need for tailored approaches in this age group.

Approach:
    Key Findings:
    • FNH is a benign hyperplastic response to vascular malformations, not a true neoplasm.
    • In adolescents, FNH can present with significant clinical variability, including symptoms that may mimic hepatocellular adenoma (HCA).
    • Surgical intervention is often necessary for definitive diagnosis in adolescents with atypical hepatic lesions exceeding 5 cm, particularly when imaging is inconclusive.
    Interpretation:

    The case underscores the need for proactive surgical intervention in adolescents with indeterminate hepatic lesions, as conservative management may overlook potential risks associated with misdiagnosis.

    Limitations:
    • The study is based on a single case report, limiting generalizability.
    • The literature review may not encompass all recent findings or variations in clinical practice, and potential biases in selection may affect the conclusions drawn.
    Conclusion:

    Surgical intervention may provide a definitive diagnosis and treatment for adolescents with atypical hepatic lesions, ensuring better long-term outcomes and highlighting the need for tailored management strategies.

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