Risk-score performance for detecting transthyretin cardiac amyloidosis in severe aortic stenosis: a prospective cohort study - Summary - MDSpire

Risk-score performance for detecting transthyretin cardiac amyloidosis in severe aortic stenosis: a prospective cohort study

  • By

  • Graczyk Katarzyna

  • Dziewięcka Ewa

  • Winiarczyk Mateusz

  • Stępień Agnieszka

  • Przytuła Natalia

  • Holcman Katarzyna

  • Wiśniowska-Śmiałek Sylwia

  • Szot Wojciech

  • Kostkiewicz Magdalena

  • Rubiś Paweł

  • May 22, 2026

  • 0 min

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Objective:

To determine the prevalence of transthyretin cardiac amyloidosis (ATTR-CA) in patients with severe aortic stenosis (AS) and assess the effectiveness of specific diagnostic models, including the RAISE score and T-AMYLO score.

Key Findings:
  • 18% of patients with severe AS also had ATTR-CA.
  • Patients with ATTR-CA-AS were significantly older and had more arrhythmic disorders.
  • Higher NT-proBNP and troponin levels were found in ATTR-CA-AS patients.
  • The eRAISE model showed the highest diagnostic accuracy (AUC=0.948).
  • Patients with ATTR-CA-AS had a reduced left ventricular ejection fraction (44.6% vs. 54.7%, p = 0.03).
Interpretation:

ATTR-CA is frequently observed in patients with severe AS, and risk scores can improve diagnostic accuracy.

Limitations:
  • The study was conducted at a single tertiary hospital, which may limit generalizability to broader populations.
  • Follow-up duration was limited to 6 months, which may not capture long-term outcomes.
Conclusion:

Implementing risk scores could enhance the detection of ATTR-CA in patients with severe AS, improving clinical decision-making and patient outcomes.

Original Source(s)

Risk-score performance for detecting transthyretin cardiac amyloidosis in severe aortic stenosis: a prospective cohort study

  • by Graczyk Katarzyna, Dziewięcka Ewa, Winiarczyk Mateusz, Stępień Agnieszka, Przytuła Natalia, Holcman Katarzyna, Wiśniowska-Śmiałek Sylwia, Szot Wojciech, Kostkiewicz Magdalena, Rubiś Paweł

  • May 22, 2026

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