Relationships Between Systemic Immune-Inflammation Index and Aggregate Systemic Inflammation Index with Acute Gouty Arthritis in Males: A Cross-Sectional Analysis

To evaluate the associations of complete blood cell count-derived inflammatory markers with acute gouty arthritis specifically in males.

28.4% prevalence of acute gouty arthritis (AGA) among the study participants, with a mean age of 54 years.
Significant associations found between AGA and inflammatory markers: MLR, NLR, PLR, SII, SIRI, and AISI.
Nonlinear dose–response relationships identified between SII and AGA, and AISI and AGA.
SII and AISI demonstrated superior diagnostic accuracy compared to MLR, NLR, PLR, and SIRI.

Inflammatory markers are closely associated with AGA in males, with SII and AISI being more effective for diagnosis.

Study limited to male participants, which may affect generalizability to the broader population.
No synovial fluid aspiration for MSU crystal detection due to clinical feasibility constraints, potentially limiting diagnostic accuracy.

SII and AISI may serve as more accurate indicators for diagnosing acute gouty arthritis in men.