Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives - Summary - MDSpire

Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives

  • By

  • Manali Jain

  • Anamika Kumari Anuja

  • Soniya Yadav

  • Jasmin Ara

  • Anukool Ojha

  • Chandra Prakash Chaturvedi

  • July 14, 2026

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Objective:

To summarize the current understanding of non-coding RNAs (ncRNAs) in the pathogenesis of osteoarthritis (OA) and discuss their potential as biomarkers and therapeutic targets in clinical applications.

Approach:
  • Overview of ncRNAs: The article reviews the roles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in OA, focusing on their mechanisms of action, involvement in key signaling pathways, and potential clinical applications.
Key Findings:
  • miR-140-5p is the most validated cartilage-protective miRNA, suppressing ADAMTS5-mediated extracellular matrix degradation.
  • Other miRNAs like miR-146a, miR-21, and miR-34a regulate inflammatory signaling and chondrocyte survival.
  • Many lncRNAs and circRNAs lack extensive validation in primary human OA tissues.
  • Circulating ncRNAs show promise as minimally invasive biomarkers for OA, but current studies face methodological limitations.
Interpretation:

ncRNAs are critical regulators in OA pathogenesis and hold potential as biomarkers and therapeutic targets.

Limitations:
  • Current biomarker studies are limited by methodological heterogeneity and small cohort sizes.
  • Many ncRNAs lack extensive validation in primary human OA tissues.
  • Challenges in delivery efficiency and long-term safety of ncRNA-based therapeutics remain.
Conclusion:

ncRNAs represent promising molecular regulators and potential therapeutic targets for OA.

Original Source(s)

Non-coding RNA in osteoarthritis: mechanistic insights and future perspectives

  • by Manali Jain, Anamika Kumari Anuja, Soniya Yadav, Jasmin Ara, Anukool Ojha, Chandra Prakash Chaturvedi

  • July 14, 2026

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