Objective:

To assess the safety and diagnostic adequacy of core needle biopsy guided by ultrasonography in individuals with pelvic tumors and to determine diagnostic accuracy for patients who underwent surgical assessment.

Approach:

• Study Design: Multicenter, prospective cohort investigation conducted at four high-volume gynecologic oncology centers.
• Participants: Consecutive patients undergoing core needle biopsies of pelvic lesions from May 26, 2021, to December 31, 2024.
• Biopsy Techniques: Biopsies performed using transvaginal, transrectal, or percutaneous methods based on lesion localization and morphology.
• Data Collection: Clinical characteristics, medication administration, biopsy indications, and method were documented.
• Safety Evaluation: Complication rates assessed immediately post-procedure and via follow-up telephone assessments after 6 weeks.

Key Findings:

• Core needle biopsy allows for histologic examination and immunohistochemical analysis.
• Ultrasonography-guided biopsy achieves high diagnostic accuracy and low complication rates.
• The study adhered to STROBE guidelines and received ethical approval from the institutional review boards of all participating centers.

Interpretation:

The results indicate that core needle biopsy guided by ultrasonography is a safe and effective method for obtaining tissue samples from pelvic tumors. The high diagnostic accuracy suggests that this technique can significantly aid in the clinical decision-making process for patients with suspected malignancies. The low complication rates further support its use as a reliable diagnostic tool in gynecologic oncology.

Limitations:

• The majority of prior studies on this topic have been retrospective or limited in scope.
• The study's findings may not be generalizable beyond the participating centers, and further research is needed to validate these results in broader populations.

Conclusion:

Core needle biopsy guided by ultrasonography is a valuable diagnostic approach for evaluating pelvic tumors, providing essential histological information with minimal risk to patients. Future studies should aim to confirm these findings in larger, more diverse populations to enhance the applicability of this technique in clinical practice.