To analyze subchondral bone remodeling in larger animal models of knee osteoarthritis induced by meniscal injuries, highlighting its significance for understanding OA.
Key Findings:
Subchondral bone plate and subarticular spongiosa exhibit structural differences across species, impacting OA progression.
Human subchondral bone plate is thinner compared to larger animals like sheep and minipigs, which may influence translational research.
Subchondral bone changes occur early in OA, including increased porosity and decreased bone density, indicating early intervention opportunities.
Only 23 studies met the criteria for detailed evaluation, indicating a significant gap in research that needs addressing.
Interpretation:
The findings highlight significant structural differences in subchondral bone across species, which are crucial for understanding OA progression and for designing relevant animal studies, emphasizing the need for targeted research.
Limitations:
Limited number of studies specifically addressing subchondral bone in larger animal models, which may skew understanding of OA.
Exclusion of studies with combined methods that may influence results, potentially overlooking relevant data.
Conclusion:
The review underscores the urgent need for more focused research on subchondral bone remodeling in larger animal models to better understand OA mechanisms and improve translational outcomes.
