Advancements in Understanding TWEAK/Fn14 Pathway in the Healing of Chronic Wounds
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By
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Wu, Weimin
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Liu, Bo
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Lan, Tianyao
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Hu, Weigang
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Zheng, Huarong
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April 3, 2026
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Objective:
To summarize the role of the TWEAK/Fn14 signaling pathway in chronic wound healing and its potential as a therapeutic target.
Key Findings:
- Chronic wounds are marked by prolonged healing due to persistent inflammation.
- TWEAK plays a crucial role in regulating cellular processes involved in wound repair.
- The TWEAK/Fn14 pathway presents a promising target for therapeutic interventions in chronic wound healing.
Interpretation:
Understanding the TWEAK/Fn14 pathway could lead to novel treatments that enhance healing in chronic wounds.
Limitations:
- The review may not cover all recent studies or alternative pathways involved in wound healing.
- Further clinical research is needed to validate the therapeutic potential of targeting the TWEAK/Fn14 pathway.
Conclusion:
Targeting the TWEAK/Fn14 signaling pathway may offer new strategies for improving chronic wound healing outcomes.
