Assessing HIV Vulnerability and the Use of Oral Pre-Exposure Prophylaxis (PrEP) in Injecting Drug Users in Nairobi: A Cross-Sectional Analysis - Summary - MDSpire

Assessing HIV Vulnerability and the Use of Oral Pre-Exposure Prophylaxis (PrEP) in Injecting Drug Users in Nairobi: A Cross-Sectional Analysis

  • By

  • Cosmas Mugambi

  • Loice Mbogo

  • William Sinkele

  • Esther Gitau

  • Tecla Temu

  • Carey Farquhar

  • David Bukusi

  • John Kinuthia

  • Aliza Monroe-Wise

  • January 5, 2026

  • 0 min

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Objective:

To characterize the risks of HIV acquisition and assess PrEP knowledge and use among people who inject drugs (PWID) in Nairobi, along with specific factors such as stigma, socioeconomic status, and healthcare access associated with PrEP awareness and use.

Key Findings:
  • HIV prevalence among PWID in Kenya was estimated at 18.7% in 2021, highlighting a critical public health concern.
  • PrEP can reduce HIV acquisition risk from drug injection by 74% and from sex by 99%, underscoring its importance.
  • Many PWID are unaware of PrEP or have misconceptions about its use, leading to low uptake, which poses a risk to public health.
  • Provider-level barriers, stigma, and socioeconomic factors hinder access to PrEP among PWID, necessitating urgent intervention.
Interpretation:

The study highlights significant gaps in PrEP awareness and utilization among PWID, emphasizing the urgent need for targeted interventions to improve knowledge and access, particularly in marginalized communities.

Limitations:
  • The study's cross-sectional design limits causal inference.
  • Potential biases in self-reported data may affect the accuracy of findings.
  • The sample may not be representative of all PWID in Nairobi, particularly given the timing of the study during a public health crisis.
Conclusion:

Improving PrEP uptake among PWID is crucial for reducing HIV transmission; tailored strategies addressing specific barriers, including stigma and access to healthcare, are needed.

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