Morphological Changes in the Cornea Following Cessation of Long-Term Orthokeratology and Outcomes of SMILE Surgery: A Retrospective Comparative Analysis - Summary - MDSpire

Morphological Changes in the Cornea Following Cessation of Long-Term Orthokeratology and Outcomes of SMILE Surgery: A Retrospective Comparative Analysis

  • By

  • Kun Zhou

  • Xiaohuan Ma

  • Di Shen

  • Wenjia Cao

  • Xiyu Sun

  • Mengchen Li

  • Wei Wei

  • February 13, 2026

  • 0 min

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Objective:

To investigate ocular biometric and corneal morphological alterations after long-term orthokeratology (OK) lens discontinuation and assess their impact on SMILE outcomes, specifically focusing on visual acuity and corneal parameters, compared to patients without a history of OK wear.

Key Findings:
  • Long-term OK lens wear resulted in residual corneal flattening and increased astigmatism, which may impact visual outcomes.
  • Corneal morphology changes persisted even after cessation of OK lens use, indicating potential long-term effects.
  • SMILE outcomes were comparable between OK users and non-users; however, pre-existing corneal changes may influence surgical results.
Interpretation:

The study highlights the importance of understanding corneal changes post-OK lens wear, as these may affect surgical outcomes in refractive procedures like SMILE.

Limitations:
  • Small sample size may limit generalizability and statistical power.
  • Retrospective design may introduce selection bias, affecting the reliability of the findings.
Conclusion:

Further research is needed to fully understand the implications of corneal morphological changes from long-term OK use on refractive surgery outcomes, particularly in larger, prospective studies.

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