Exploring the mechanism of acupuncture improving cognitive functions for post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome: study protocol of a randomized controlled trial with multimodal MRI - Summary - MDSpire

Exploring the mechanism of acupuncture improving cognitive functions for post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome: study protocol of a randomized controlled trial with multimodal MRI

  • By

  • Luo, Tingting

  • Luo, Yang

  • Huang, Liang

  • Jin, Hongjiao

  • An, Yi

  • Huang, Jingwei

  • Luo, Kun

  • Guo, Yan

  • Wang, Dan

  • Liu, Dafeng

  • Wu, Xi

  • May 15, 2026

  • 0 min

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Objective:

To evaluate the efficacy of acupuncture treatment in improving cognitive function for post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome (PCME/CFS) and to investigate the neural mechanisms involved.

Key Findings:
  • Acupuncture is a complementary therapy for ME/CFS with potential benefits for cognitive dysfunction.
  • The study aims to clarify the effects and mechanisms of acupuncture on cognitive function in PCME/CFS.
Interpretation:

The study will preliminarily explore the efficacy of acupuncture therapy in improving cognitive function and its potential mechanisms.

Limitations:
  • Potential biases in patient selection and the subjective nature of cognitive assessments.
Conclusion:

The results will provide insights into whether acupuncture can enhance cognitive function in PCME/CFS through metabolic and connectivity changes in the hippocampus.

Original Source(s)

Exploring the mechanism of acupuncture improving cognitive functions for post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome: study protocol of a randomized controlled trial with multimodal MRI

  • by Luo, Tingting , Luo, Yang , Huang, Liang , Jin, Hongjiao , An, Yi , Huang, Jingwei , Luo, Kun , Guo, Yan , Wang, Dan , Liu, Dafeng , Wu, Xi

  • May 15, 2026

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