To report a rare case of non-secretory multiple myeloma (NSMM) presenting with marked eosinophilia and to highlight the significant diagnostic challenges associated with this condition.
Key Findings:
The patient exhibited persistent eosinophilia and negative results for conventional monoclonal protein tests, complicating the diagnosis.
Bone marrow analysis revealed clonal plasma cells and abnormalities consistent with multiple myeloma, indicating a serious underlying condition.
The coexistence of marked eosinophilia complicated the diagnostic process, leading to potential misdiagnosis and delayed treatment.
Interpretation:
This case underscores the importance of integrating various diagnostic modalities, including bone marrow findings and cytogenetic evaluations, in atypical presentations of multiple myeloma to ensure accurate diagnosis.
Limitations:
The patient declined further imaging (PET/CT) due to financial constraints, limiting the assessment of skeletal involvement and potentially affecting treatment decisions.
The rarity of NSMM with eosinophilia means limited literature is available for comparison, which may hinder broader understanding.
Conclusion:
The coexistence of eosinophilia in NSMM can obscure the diagnosis, necessitating a thorough evaluation to avoid misdiagnosis and ensure timely treatment, highlighting the need for increased clinical awareness.
