Objective:

To characterize a circulating damage-associated molecular pattern (DAMP)-related signature linked to systemic inflammatory signaling in diabetic foot syndrome (DFS).

Approach:

Key Findings:

• Identified differences in the abundance of multiple acute-phase and stress-associated proteins, including serum amyloid A1, serum amyloid A2, serum amyloid P component, S100A8, defensin alpha 1B, fibrinogen chains, heat shock protein family A member 5, thymosin beta 4, fibronectin 1, and tenascins, between DFS patients and diabetic controls.
• Several DAMPs exhibited reproducible patterns, indicating a coordinated circulating molecular pattern.
• TLR4 inhibition in diabetic ischemic mice altered the abundance of several circulating proteins, including reductions in selected amyloid-associated proteins.

Interpretation:

Limitations:

• The study had a limited sample size of 33 patients.
• Exclusion criteria may limit generalizability to broader diabetic populations.

Conclusion:

Sources:

• ProteomeXchange
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