Retrospective study on the treatment of osteoporotic vertebral compression fractures with alfacalcidol and percutaneous kyphoplasty - Summary - MDSpire
Advertisement
Retrospective study on the treatment of osteoporotic vertebral compression fractures with alfacalcidol and percutaneous kyphoplasty
To evaluate the clinical efficacy of percutaneous kyphoplasty (PKP) combined with alfacalcidol in the treatment of osteoporotic vertebral compression fractures (OVCF), and to explore the impact on bone metabolism and functional recovery.
Approach:
Study Design: Retrospective study including 120 patients with single-level OVCFs who underwent PKP.
Patient Groups: Patients divided into two groups: basic treatment group (BT, n = 60) and alfacalcidol group (AFC, n = 60).
Clinical Parameters: Parameters recorded included bone mineral density (BMD), bone metabolism markers, Visual Analog Scale (VAS) for pain, and Japanese Orthopaedic Association (JOA) scores preoperatively and at 6 and 12 months postoperatively.
Key Findings:
Both groups showed significant postoperative improvement in BMD, VAS, and JOA scores (P < 0.05).
The AFC group demonstrated greater increases in BMD and more pronounced reductions in bone turnover markers at both follow-up points (P < 0.05).
Pain relief and functional recovery were significantly better in the AFC group (P < 0.05).
No serious adverse events were observed.
Interpretation:
Limitations:
Retrospective design may introduce selection bias.
Exclusion of other anti-osteoporosis medications limits generalizability.
