Targeting Liver Metastases in Uveal Melanoma: ATX-LPA Mediated Immunosuppression and Novel Therapeutic Approaches

By
A. Turner, Jacqueline
D'Antonio, Marc
Montane, Heather
MacBeth, Morgan
Katsnelson, Elizabeth
Robinson, William
Tobin, Richard
Couts, Kasey L.
Markovic, Svetomir N
Torres, Raul M
May 29, 2026
0 min

Frontiers In Immunology

Objective:

To investigate molecular pathways regulating hepatic CD8+ T cell function and evaluate clinical outcomes associated with liver-directed therapy in uveal melanoma, particularly focusing on immune suppression mechanisms.

Approach:

Key Findings:

The ATX enzyme is constitutively expressed by hepatic resident cells and is associated with increased immunosuppressive markers.
CD8+ T cells from hepatic metastasis exhibit significantly elevated ATX transcripts.
LPA signaling leads to dysfunctional ERK signaling in CD8+ T cells.

Interpretation:

Conclusion:

The study highlights the ATX-LPA pathway as a potential target for further investigation in liver-directed clinical interventions.

Original Source(s)

Frontiers In Immunology

Targeting Liver Metastases in Uveal Melanoma: ATX-LPA Mediated Immunosuppression and Novel Therapeutic Approaches

by A. Turner, Jacqueline , D'Antonio, Marc , Montane, Heather , MacBeth, Morgan , Katsnelson, Elizabeth , Robinson, William , Tobin, Richard , Couts, Kasey L., Markovic, Svetomir N, Torres, Raul M
May 29, 2026

Targeting Liver Metastases in Uveal Melanoma: ATX-LPA Mediated Immunosuppression and Novel Therapeutic Approaches

Objective:

Approach:

Key Findings:

Interpretation:

Conclusion:

Original Source(s)

Targeting Liver Metastases in Uveal Melanoma: ATX-LPA Mediated Immunosuppression and Novel Therapeutic Approaches

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