Exercise testing in athletes: an adjunct to diagnose arrhythmogenic cardiomyopathy? - Summary - MDSpire

Evaluating Exercise Testing in Athletes as a Tool for Diagnosing Arrhythmogenic Cardiomyopathy

  • By

  • Simon Wernhart

  • Martin Halle

  • Mark J. Haykowsky

  • Satyam Sarma

  • July 20, 2026

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Objective:

To explore the potential of combined stress echocardiography and cardiopulmonary exercise testing (CPET echocardiography) in differentiating physiological adaptations from cardiomyopathic changes in athletes suspected of arrhythmogenic cardiomyopathy (ACM).

Approach:
  • Method: label
  • Method: text
Key Findings:
  • Current diagnostic criteria for ACM may not adequately address the complexities in highly trained athletes.
  • Nearly one-third of elite athletes exhibit right ventricular dilatation, complicating the diagnosis of ACM.
  • Exercise testing can reveal regional wall motion abnormalities and inadequate increases in ejection fraction, indicating potential underlying pathology.
Interpretation:

A Qc/VO2 slope <5 may indicate central limitations potentially due to subclinical ACM in athletes.

Limitations:
  • The Qc/VO2 slope cut-off <5 as an indicator of cardiomyopathy is hypothesis-generating and requires further validation.
  • High endurance training may alter stroke volume dynamics, complicating the interpretation of exercise testing results.
Conclusion:

Integrating CPET echocardiography may enhance the diagnostic framework for ACM in athletes.

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