New insights from MRI-guided laser interstitial thermal therapy for refractory epilepsy: a state-of-the-art overview - Summary - MDSpire

New insights from MRI-guided laser interstitial thermal therapy for refractory epilepsy: a state-of-the-art overview

  • By

  • Carlos Quispe-Vicuña

  • Fernando Terry

  • Miguel Cabanillas-Lazo

  • Alejandro Enríquez-Marulanda

  • Niels Pacheco-Barrios

  • Forough Yazdanian

  • J. Pierre Zila-Velasque

  • David R. Soriano-Moreno

  • Christian Moran-Mariños

  • Evan Luther

  • Lekhaj Daggubati

  • Martin Merenzon

  • Jaime Lopez-Calle

  • Jorge G. Burneo

  • Ricardo J. Komotar

  • Ziev B. Moses

  • John D. Rolston

  • Carlos Alva-Diaz

  • May 29, 2026

  • 0 min

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Objective:

To conduct a systematic review of systematic reviews to provide a descriptive assessment of the quality of evidence regarding the application of MRgLITT for DRE.

Key Findings:
  • 16 systematic reviews included observational studies.
  • 14 systematic reviews scored 'Critically low' with a median score of 8.
  • Seizure freedom rate ranged from 18.87% to 75.86%; most common cause of DRE was mesial temporal lobe epilepsy.
  • Common complications included visual field deficit (2.17%–7.5%) and intracranial hemorrhage (0.96%–8.6%).
  • All outcomes reported a 'very low' certainty of evidence due to absence of randomized studies.
Interpretation:

Limitations:
  • Lack of standardized clinical guidelines for MRgLITT.
  • Absence of randomized controlled trials in the included systematic reviews.
  • Heterogeneity in findings and methodologies across studies.
Conclusion:

Original Source(s)

New insights from MRI-guided laser interstitial thermal therapy for refractory epilepsy: a state-of-the-art overview

  • by Carlos Quispe-Vicuña, Fernando Terry, Miguel Cabanillas-Lazo, Alejandro Enríquez-Marulanda, Niels Pacheco-Barrios, Forough Yazdanian, J. Pierre Zila-Velasque, David R. Soriano-Moreno, Christian Moran-Mariños, Evan Luther, Lekhaj Daggubati, Martin Merenzon, Jaime Lopez-Calle, Jorge G. Burneo, Ricardo J. Komotar, Ziev B. Moses, John D. Rolston, Carlos Alva-Diaz

  • May 29, 2026

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