Autologous platelet-rich fibrin (PRF) augmentation as an add-on therapy in deep surgical site infections (dSSIs) after instrumented spinal surgery: preliminary results of a single institution case series - Summary - MDSpire

Autologous platelet-rich fibrin (PRF) augmentation as an add-on therapy in deep surgical site infections (dSSIs) after instrumented spinal surgery: preliminary results of a single institution case series

  • By

  • Ioannis Vasilikos

  • Roland Roelz

  • Christoph Scholz

  • Boris Mizaikoff

  • Katerina Argiti

  • Watzlawick Ralf

  • Georgios-Christos Giagkos

  • Evangelos M. Fragkakis

  • Shahram Ghanaati

  • Jürgen Beck

  • Ulrich Hubbe

  • August 24, 2021

  • 0 min

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Objective:

To evaluate the effectiveness of autologous platelet-rich fibrin (PRF) as an adjunct therapy for deep surgical site infections (dSSIs) following spinal surgery, addressing a significant complication in postoperative recovery.

Key Findings:
  • 12 patients with dSSIs were treated with PRF augmentation after failing standard therapies, with notable improvements in healing rates and reduced infection signs.
  • PRF contains high concentrations of growth factors that may enhance wound healing.
  • The use of PRF led to improved outcomes in the management of dSSIs, including reduced healing time and lower infection recurrence.
Interpretation:

The preliminary results suggest that PRF augmentation may be a beneficial adjunctive therapy for patients with persistent dSSIs after spinal surgery, potentially improving healing outcomes and reducing the need for further interventions.

Limitations:
  • Small sample size of 12 patients limits generalizability.
  • Lack of a control group for comparison with standard treatment outcomes.
  • No long-term follow-up data to assess the durability of the treatment effects.
Conclusion:

PRF augmentation shows promise as an effective add-on therapy for managing dSSIs in spinal surgery, warranting further investigation in larger studies to confirm these preliminary findings.

Original Source(s)

Autologous platelet-rich fibrin (PRF) augmentation as an add-on therapy in deep surgical site infections (dSSIs) after instrumented spinal surgery: preliminary results of a single institution case series

  • by Ioannis Vasilikos, Roland Roelz, Christoph Scholz, Boris Mizaikoff, Katerina Argiti, Watzlawick Ralf, Georgios-Christos Giagkos, Evangelos M. Fragkakis, Shahram Ghanaati, Jürgen Beck, Ulrich Hubbe

  • August 24, 2021

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