To characterize the associations between baseline TyG index and subsequent sepsis incidence and all-cause mortality, and to determine if these associations are modified by diabetes status.
Key Findings:
12,410 sepsis events and 6,291 sepsis-related deaths were documented over a median follow-up of 13.04 years.
In diabetic individuals, each 1-unit increase in the TyG index was associated with an 18% higher risk of sepsis and a 16% higher risk of sepsis-related mortality.
In non-diabetic participants, no significant associations were observed for sepsis incidence or mortality.
Interpretation:
The TyG index is linearly associated with increased risks of sepsis and sepsis-related mortality in diabetic individuals, while no significant associations exist in non-diabetic individuals.
Limitations:
The study is observational and cannot establish causation.
Findings may not be generalizable beyond the UK Biobank population.
Conclusion:
The TyG index may serve as a clinically useful biomarker for sepsis risk stratification in patients with diabetes, warranting further validation in external cohorts.
