To identify expert agreement on the appropriateness and clinical relevance of sex and gender-tailored colorectal cancer screening strategies.
Approach:
Literature Review: A comprehensive literature review was conducted to examine existing evidence on sex-and gender-related differences in colorectal cancer.
Expert Consensus: A multidisciplinary panel of experts convened to develop consensus statements using the RAND/UCLA Appropriateness Method.
Key Findings:
Significant disparities exist between men and women in incidence, age at onset, lesion distribution, participation rates, and barriers to screening.
Interpretation:
Core statements emphasize the importance of collecting and analyzing sex-disaggregated data, promoting further research, and tailoring communication strategies to improve screening adherence.
Limitations:
The study may be limited by the availability and quality of existing literature on sex and gender differences in colorectal cancer.
Potential biases in expert consensus formation may affect the recommendations.
Conclusion:
The study highlights the necessity for personalized and precision medicine approaches in colorectal cancer screening.
by Marta Bianchini, Tiziana Vavalà, Francesca Rossi, Elsa Vitale, Manuel Zorzi, Stefania Gori, Rossana Berardi, Anna Maria Moretti, Marialuisa Appetecchia
