To report a rare case of gastric spasm as an adverse drug reaction caused by polymyxin B used for treating a carbapenem-resistant Acinetobacter baumannii infection.
Approach:
Key Findings:
Polymyxin B may induce gastric spasm in children by elevating histamine levels.
Increased histamine enhances gastric acid secretion and triggers an inflammatory response.
The Naranjo algorithm indicated a probable causal link between polymyxin B and gastric spasm with a score of +6.
Interpretation:
The findings suggest that polymyxin B can cause gastric spasm, a previously unreported adverse reaction.
Limitations:
The study is based on a single case report, limiting generalizability.
The exact mechanism of how polymyxin B induces gastric spasm remains unclear.
Conclusion:
Polymyxin B should be monitored for potential gastric spasm in pediatric patients, as evidenced by this case.
