Maternal and Pediatric Use of Vaccines for Mpox: A Living Systematic Review and Meta-analysis of Safety and Effectiveness - Summary - MDSpire

Maternal and Pediatric Use of Vaccines for Mpox: A Living Systematic Review and Meta-analysis of Safety and Effectiveness

  • By

  • Ciapponi, Agustín

  • Ballivian, Jamile

  • Berrueta, Mabel

  • Sambade, Juan M.

  • Castellana, Noelia

  • Bardach, Ariel

  • Brizuela, Martin

  • Caravario, Julieta

  • Comande, Daniel

  • Couto, Esteban

  • Mazzoni, Agustina

  • Parker, Edward

  • Salva, Florencia

  • Stegelmann, Katharina

  • Xiong, Xu

  • Stergachis, Andy

  • Munoz, Flor M.

  • Buekens, Pierre

  • March 6, 2026

  • 0 min

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Objective:

To evaluate the safety and efficacy of vaccinia-based vaccines against mpox in pregnant individuals and children through a living systematic review, emphasizing the need for ongoing evidence synthesis.

Key Findings:
  • First-generation vaccines showed a slight increase in congenital anomalies; second- and third-generation vaccines did not, indicating a potential shift in safety profiles.
  • Serious adverse events in children are rare and typically mild, suggesting a favorable safety profile.
  • Limited safety data for third-generation mpox vaccines in pregnancy and pediatric populations highlights the need for further research.
Interpretation:

While newer vaccines appear safer for pregnant individuals and children, ongoing studies and improved pharmacovigilance are essential due to limited existing data, underscoring the urgency for further investigation.

Limitations:
  • Pregnant persons and children were largely excluded from initial vaccine trials, limiting the applicability of findings.
  • Existing observational data is minimal and primarily from adult populations, which may not accurately reflect safety in vulnerable groups.
Conclusion:

A living systematic review is necessary to continuously integrate emerging evidence on the safety and efficacy of mpox vaccines for vulnerable populations, reinforcing the importance of adaptive public health responses.

Original Source(s)

Maternal and Pediatric Use of Vaccines for Mpox: A Living Systematic Review and Meta-analysis of Safety and Effectiveness

  • by Ciapponi, Agustín, Ballivian, Jamile, Berrueta, Mabel, Sambade, Juan M., Castellana, Noelia, Bardach, Ariel, Brizuela, Martin, Caravario, Julieta, Comande, Daniel, Couto, Esteban, Mazzoni, Agustina, Parker, Edward, Salva, Florencia, Stegelmann, Katharina, Xiong, Xu, Stergachis, Andy, Munoz, Flor M., Buekens, Pierre

  • March 6, 2026

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