Comparison of Mental Health Outcomes Following Major and Minor Upper Limb Amputations: A Retrospective Analysis Using National Database Data - Summary - MDSpire

Comparison of Mental Health Outcomes Following Major and Minor Upper Limb Amputations: A Retrospective Analysis Using National Database Data

  • By

  • Victoria Nedder

  • Joyce Wang

  • Kacy Peek

  • April 23, 2026

  • 0 min

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Objective:

To identify differences in mental health outcomes and needs for patients undergoing minor versus major upper extremity amputations, including new mental health disorder diagnoses, psychotherapy care, and antidepressant medication use, specifically focusing on depression, anxiety, and drug-related disorders.

Key Findings:
  • Major amputation patients had significantly higher rates of new mental health diagnoses at 90 days (18.5% vs. 6.9%) and one year (29.2% vs. 17.7%) compared to minor amputation patients.
  • Depression and anxiety were the most common disorders in major amputations, while drug-related disorders were more prevalent in minor amputations.
  • Antidepressant usage was higher in major amputations at both 90 days (11.7% vs. 3.7%) and one year (21.3% vs. 10.7%).
Interpretation:

Major upper extremity amputations are associated with significantly worse mental health outcomes compared to minor amputations, highlighting the need for targeted psychological interventions.

Limitations:
  • The study is retrospective and relies on database records, which may not capture all relevant mental health outcomes, potentially underestimating the prevalence of disorders.
  • Exclusion of patients with pre-existing mental health conditions may limit generalizability, as these individuals may have different needs and outcomes.
Conclusion:

Patients undergoing major upper extremity amputations are at a higher risk for mental health disorders and require more intensive psychological support compared to those with minor amputations.

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