Objective:

To investigate the effects of aerobic and resistance training during neoadjuvant chemotherapy on sleep quality and cancer-related fatigue, and to compare these effects with those of resistance training conducted post-surgery.

Key Findings:

• Exercise interventions during neoadjuvant chemotherapy may alleviate cancer-related fatigue and improve sleep quality.
• Aerobic training and resistance training both showed potential benefits, but the comparative effectiveness needs further exploration.
• No significant differences were observed between the exercise interventions and the waitlist control group regarding sleep quality and fatigue levels.

Interpretation:

The findings suggest that exercise during neoadjuvant chemotherapy could be beneficial for managing symptoms of cancer-related fatigue and sleep disturbances; however, further research is essential to establish definitive conclusions.

Limitations:

• The study did not specifically screen participants for pre-existing sleep disturbances or cancer-related fatigue, which may affect the generalizability of the findings.
• Blinding of participants was not feasible due to the nature of exercise interventions.

Conclusion:

Exercise during neoadjuvant chemotherapy may provide clinical benefits in managing fatigue and sleep quality, warranting further investigation into optimal exercise timing and types.