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Engineering Safer Editors for Cystic Fibrosis Mutations 

Modified APOBEC3G editors improve CRISPR base-editing specificity and reduce bystander mutations in human cells

  • March 13, 2026

  • 2 min

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Engineers from the University of Pennsylvania and Rice University have developed new DNA base-editing tools aimed at enhancing gene-editing safety for diseases like cystic fibrosis. Focusing on cytosine base editors (CBEs), they engineered variants to improve precision by reducing unintended edits near target sites. The modified tools, which significantly decreased unintended changes to less than 1%, successfully introduced and corrected mutations in human bronchial epithelial cells, offering potential advancements in gene therapies and cellular models for studying genetic disorders.

Original Source(s)

Engineering Safer Editors for Cystic Fibrosis Mutations 

  • March 13, 2026

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