Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO2max and speckle tracking echocardiography - Summary - MDSpire
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Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO2max and speckle tracking echocardiography
To assess changes in aerobic performance and cardiac morphology/function in prepubertal children with short stature undergoing r-hGH therapy.
Key Findings:
r-hGH significantly increased IGF-1 and left ventricular mass indices.
VO2max showed no overall improvement; a significant decrease was observed in GHD children, particularly girls.
Only GHD males exhibited supranormal VO2max values at baseline, which persisted at 12 months.
GLSR improved significantly at 6 months in GHD patients, indicating early myocardial response to GH therapy.
No correlation was found between VO2max evolution and cardiac parameters.
Interpretation:
The findings suggest that r-hGH therapy has beneficial effects on IGF-1 levels and left ventricular mass indices, but also highlight a decline in aerobic performance in certain groups.
Limitations:
Small sample size of 30 participants.
Short follow-up duration of only 12 months.
Conclusion:
The study indicates that r-hGH therapy can lead to increases in IGF-1 and left ventricular mass indices in short-statured children. However, it also highlights a decline in VO2max among GHD children, particularly in girls, and suggests that while GLSR improves, there is no correlation between changes in VO2max and cardiac parameters.
by Ignacio Ruiz del Olmo-Izuzquiza, Antonio de Arriba-Muñoz, Lorenzo Jiménez-Montañés, Ángel Matute-Llorente, Marta Vara-Callau, Marta Ferrer-Lozano, José-Antonio Casajús-Mallén, José-Ignacio Labarta-Aizpún
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