Volumetric measurement of terminal ileal Crohn’s disease by magnetic resonance enterography: a feasibility study - Summary - MDSpire

Volumetric measurement of terminal ileal Crohn’s disease by magnetic resonance enterography: a feasibility study

  • By

  • Shankar Kumar

  • Nikhil Rao

  • Anisha Bhagwanani

  • Thomas Parry

  • Maira Hameed

  • Safi Rahman

  • Heather E. Fitzke

  • Judith Holmes

  • Benjamin Barrow

  • Andrew Bard

  • Alex Menys

  • David Bennett

  • Sue Mallett

  • Stuart A. Taylor

  • July 19, 2024

  • 0 min

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Objective:

To evaluate the technical feasibility of volumetric measurement of terminal ileal Crohn's disease (CD) using magnetic resonance enterography (MRE), explore the relationship between volume and disease activity, and assess volumetric changes in response to biologic therapy.

Key Findings:
  • Volumetric measurement of terminal ileal CD using MRE is technically feasible.
  • Inter-observer agreement for volumetric assessment was evaluated.
  • Volumetric changes may reflect disease activity and response to treatment.
Interpretation:

Volumetric assessment may provide a more comprehensive evaluation of disease burden in Crohn's disease compared to traditional 2D measurements, potentially improving monitoring and treatment response assessment.

Limitations:
  • Study limited to a small sample size of 30 patients.
  • Retrospective design may introduce bias.
  • Volumetric assessment not yet widely implemented in clinical practice.
Conclusion:

Volumetric measurement of terminal ileal Crohn's disease by MRE shows promise as a more responsive imaging biomarker, warranting further investigation in larger cohorts.

Original Source(s)

Volumetric measurement of terminal ileal Crohn’s disease by magnetic resonance enterography: a feasibility study

  • by Shankar Kumar, Nikhil Rao, Anisha Bhagwanani, Thomas Parry, Maira Hameed, Safi Rahman, Heather E. Fitzke, Judith Holmes, Benjamin Barrow, Andrew Bard, Alex Menys, David Bennett, Sue Mallett, Stuart A. Taylor

  • July 19, 2024

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