Immediate prediction of post-ERCP pancreatitis: a novel approach using serum trypsin - Summary - MDSpire

Immediate prediction of post-ERCP pancreatitis: a novel approach using serum trypsin

  • By

  • Takashi Tamura

  • Seiji Fujigaki

  • Tsuyoshi Sanuki

  • Tetsuya Ikeda

  • Satoshi Sugimori

  • Tsukasa Ikeura

  • Shinji Nakayama

  • Tomoya Emori

  • Kazuhiro Fukatsu

  • Yasutaka Ishii

  • Shiro Oka

  • Kenji Ikezawa

  • Ryoji Takada

  • Masanori Asada

  • Ayana Kishibuchi

  • Takeshi Ogura

  • Nobu Nishioka

  • Masaaki Shimatani

  • Masataka Kano

  • Arata Sakai

  • Kae Nagao

  • Shuhei Shintani

  • Osamu Inatomi

  • Masayuki Kitano

  • July 7, 2026

  • 0 min

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Objective:

To clarify the utility of serum trypsin (TRY) as a predictive marker for post-ERCP pancreatitis (PEP) in a multicenter study conducted across 12 hospitals in Japan.

Approach:
  • Patient Inclusion: Patients aged ≥ 20 scheduled for ERCP with intact papilla were included, while those with acute pancreatitis or specific exclusions such as prior sphincterotomy or papillary balloon dilation were not.
Key Findings:
  • Serum TRY levels increased more than other pancreatic enzymes immediately after ERCP in patients who developed PEP, indicating a potential for earlier detection.
  • The diagnostic performance of TRY in the immediate post-ERCP period was suggested to be superior to that of AMY and LIP, although statistical significance was not detailed.
Interpretation:

The study aims to establish TRY as an earlier indicator for PEP compared to traditional markers.

Limitations:
  • The previous pilot study had a small sample size and limited centers, which may affect the generalizability of the findings.
  • The current study's findings may still require further validation in diverse populations to confirm the utility of TRY.
Conclusion:

The study seeks to enhance early detection of PEP through serum TRY measurement.

Original Source(s)

Immediate prediction of post-ERCP pancreatitis: a novel approach using serum trypsin

  • by Takashi Tamura, Seiji Fujigaki, Tsuyoshi Sanuki, Tetsuya Ikeda, Satoshi Sugimori, Tsukasa Ikeura, Shinji Nakayama, Tomoya Emori, Kazuhiro Fukatsu, Yasutaka Ishii, Shiro Oka, Kenji Ikezawa, Ryoji Takada, Masanori Asada, Ayana Kishibuchi, Takeshi Ogura, Nobu Nishioka, Masaaki Shimatani, Masataka Kano, Arata Sakai, Kae Nagao, Shuhei Shintani, Osamu Inatomi, Masayuki Kitano

  • July 7, 2026

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