Objective:

To evaluate the effectiveness of polarization-sensitive optical coherence tomography (PS-OCT) combined with artificial intelligence (AI) in diagnosing subclinical keratoconus and aiding refractive surgery decisions.

Approach:

Key Findings:

• Overall accuracy for PS-OCT was 82%, while Pentacam and MS-39 achieved 86%.
• PS-OCT classified 43 of 109 subclinical keratoconus eyes as healthy, compared to 30 for Pentacam and 33 for MS-39.
• In highly asymmetric keratoconus cases, PS-OCT classified 21 of 33 fellow eyes as healthy, versus 12 for Pentacam and 16 for MS-39.
• PS-OCT identified subtle keratoconus cases that were classified as subclinical or uncertain by tomography-based models.

Interpretation:

Limitations:

• The study is retrospective and requires prospective longitudinal studies to validate the predictive value of PS-OCT reclassifications.

Conclusion:

Sources:

• Biophotonics Discovery
Source

Based on findings from:

Polarization-Sensitive OCT Targets Subclinical Keratoconus

The Ophthalmologist, 2026.

https://theophthalmologist.com/issues/2026/articles/june/polarization-sensitive-oct-targets-subclinical-keratoconus/

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