A Multicenter Study in Northern Italy to Evaluate the Impact of a Sepsis Bundle in Obstetric Settings: The SOS Study - Summary - MDSpire

A Multicenter Study in Northern Italy to Evaluate the Impact of a Sepsis Bundle in Obstetric Settings: The SOS Study

  • By

  • Marta Colaneri

  • Simona Biscarini

  • Lara Tiranini

  • Rebecca Pesare

  • Pietro Valsecchi

  • Elena Seminari

  • Arsenio Spinillo

  • Alessandra Bandera

  • Enrico Mario Ferrazzi

  • Andrea Gori

  • Laura Carenzi

  • Luigi Pusterla

  • Federico D’Amico

  • Alessandro Raimondi

  • Massimo Puoti

  • Elisa Vallicella

  • Gianpaolo Grisolia

  • Salvatore Casari

  • Alice Zavatta

  • Irene Cetin

  • Alice Bonetti

  • Marta Corbella

  • Fausto Baldanti

  • Patrizia Cambieri

  • Paola Brambilla

  • Catherine Klersy

  • Camilla Torriani

  • Maria Cristina Monti

  • Raffaele Bruno

  • Maternal Sepsis Group

  • Nicola Cesano

  • Veronica Bonaldo

  • Angelo Pan

  • Annalisa Abbiati

  • June 16, 2025

  • 0 min

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Objective:

To evaluate the impact of a regional sepsis management bundle on maternal and neonatal clinical outcomes and process measures in obstetric patients, highlighting its significance in improving care.

Key Findings:
  • No maternal deaths occurred in both prebundle and postbundle periods.
  • Median length of hospital stay showed no significant difference between groups.
  • Neonatal ICU admissions significantly decreased from 85.7% to 31.3% (P = .013).
  • Infectious disease consultations increased from 50.0% prebundle to 75.0% postbundle (P = .029).
Interpretation:

The implementation of the sepsis management bundle did not significantly improve maternal outcomes but was associated with a notable reduction in neonatal ICU admissions, suggesting a potential benefit in neonatal care and highlighting the need for further research.

Limitations:
  • Retrospective design may introduce bias, potentially affecting the reliability of the findings.
  • Uncertainty regarding the specific role of the bundle in observed changes.
Conclusion:

While the sepsis management bundle did not significantly alter maternal outcomes, it may have contributed to reduced neonatal ICU admissions and increased awareness among healthcare providers, emphasizing the need for continued evaluation.

Original Source(s)

A Multicenter Study in Northern Italy to Evaluate the Impact of a Sepsis Bundle in Obstetric Settings: The SOS Study

  • by Marta Colaneri, Simona Biscarini, Lara Tiranini, Rebecca Pesare, Pietro Valsecchi, Elena Seminari, Arsenio Spinillo, Alessandra Bandera, Enrico Mario Ferrazzi, Andrea Gori, Laura Carenzi, Luigi Pusterla, Federico D’Amico, Alessandro Raimondi, Massimo Puoti, Elisa Vallicella, Gianpaolo Grisolia, Salvatore Casari, Alice Zavatta, Irene Cetin, Alice Bonetti, Marta Corbella, Fausto Baldanti, Patrizia Cambieri, Paola Brambilla, Catherine Klersy, Camilla Torriani, Maria Cristina Monti, Raffaele Bruno, Maternal Sepsis Group, Nicola Cesano, Veronica Bonaldo, Angelo Pan, Annalisa Abbiati

  • June 16, 2025

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