To estimate the pooled prevalence of depression among youth with type 2 diabetes mellitus (T2DM) and explore sources of heterogeneity, emphasizing the importance of understanding these variations.
Key Findings:
Seventeen studies comprising 5,215 participants were included.
The pooled prevalence of comorbid depression in youth with T2DM was found to be 23.1% (95% CI: 18.0%–29.1%).
Substantial heterogeneity was observed (I² = 93%).
Higher prevalence of depression was associated with HbA1c < 7% (52.0%) compared to HbA1c ≥ 7% (24.0%).
Self-report scales indicated a higher prevalence (25.2%) than clinical diagnostic criteria (12.2%).
Interpretation:
The findings highlight that approximately one in four youth with T2DM experience depression, with variations in assessment methods and glycemic control contributing to the heterogeneity in prevalence rates, underscoring the need for improved clinical practices.
Limitations:
High heterogeneity among studies may affect the reliability of the pooled prevalence estimate.
Variations in study methodologies and populations could influence findings.
Potential biases in study selection may also impact the results.
Conclusion:
Standardized diagnostic procedures and early psychological screening are essential in pediatric T2DM populations to enhance mental health and diabetes management outcomes, and future research should continue to explore this critical area.
