To analyze the prognostic effects of maintaining different pulse pressure (PP) levels during the early resuscitation phase in septic shock patients, highlighting its significance in improving patient outcomes.
Key Findings:
PP24h maintained within 40–70 mmHg was associated with significantly higher survival rates.
In elderly patients (>65 years), PP24h > 70 mmHg correlated with higher mortality risk.
In younger patients (≤65 years), PP24h < 40 mmHg posed the greatest risk.
Both PP24h > 70 mmHg and < 40 mmHg were identified as independent risk factors for 28-day mortality.
Interpretation:
Maintaining PP levels between 40 and 70 mmHg during early resuscitation may reduce 28-day mortality in septic shock patients, with age influencing the PP-mortality relationship, suggesting tailored treatment strategies.
Limitations:
Retrospective design may introduce bias.
Data derived from a single institution may limit generalizability.
Potential confounding factors not accounted for in the analysis, including biases in data extraction.
Conclusion:
Targeting a PP range of 40-70 mmHg could improve outcomes in septic shock patients, particularly considering age-related differences in mortality risk, emphasizing the need for age-specific treatment strategies.
