Mpox Sequelae Persist 11 to 18 Months After Infection  - Summary - MDSpire

Mpox Sequelae Persist 11 to 18 Months After Infection 

Study supports follow-up and multidisciplinary care for persistent physical and psychosocial effects 

  • By

  • Henry Thomas

  • January 27, 2026

  • 3 min

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Objective:

To evaluate the persistence of physical and psychosocial sequelae in adults following mpox infection, specifically focusing on the population of 154 adults from New York City and Houston.

Key Findings:
  • 58% of participants had at least one persistent physical sequela.
  • Most common sequelae were appearance-related, including skin discoloration (83%) and scarring (51%).
  • 13% reported functional complications, primarily anorectal and urinary symptoms.
  • 45% experienced increased depressive symptoms and 40% increased anhedonia.
  • Persistent sequelae linked to more severe acute disease, specifically confluent lesions.
Interpretation:

Post-mpox sequelae frequently persist long-term, impacting both physical appearance and psychosocial well-being, highlighting the need for ongoing healthcare support.

Limitations:
  • Study limited to participants from specific clinics in New York City and Houston, which may affect generalizability.
  • Potential biases in self-reported health and psychosocial assessments.
Conclusion:

Long-term follow-up after mpox is essential to address persistent sequelae and their social and sexual impacts, including specific assessments for skin changes and functional complications.

Original Source(s)

Mpox Sequelae Persist 11 to 18 Months After Infection 

  • by Henry Thomas

  • January 27, 2026

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