To investigate the potential association between COVID-19 vaccination and thyroid diseases using a nationwide cohort in South Korea.
Key Findings:
No increased risk of hyperthyroidism recurrence after vaccination.
Increased risk of hypothyroidism exacerbation observed post-vaccination.
No significant differences in thyroid disease incidence based on age, sex, or vaccine type.
No increase in thyroid disease risk in adolescents aged 12 to 17 years.
Interpretation:
The study found an increased risk of exacerbation of hypothyroidism following COVID-19 vaccination, but no significant association with other thyroid diseases, supporting the overall safety of COVID-19 vaccines regarding thyroid health.
Limitations:
The study may not account for all confounding factors.
Data derived from a single country may limit generalizability.
Conclusion:
COVID-19 vaccination is associated with an increased risk of hypothyroidism exacerbation but not with most other thyroid diseases, contributing to evidence of vaccine safety.
Nearly 90% of patients who met algorithmic criteria for postacute sequelae of SARS-CoV-2 infection had at least 1 chronic or potentially chronic condition requiring ongoing clinical management.
Nearly 40% of patients initiated thyroid hormone therapy within 2 years of hemithyroidectomy, with higher preoperative thyroid‐stimulating hormone levels and thyroid cancer identifying those at greatest risk.