Real-world efficacy of stapokibart for severe olfactory dysfunction: early and sustained improvement independent of baseline type 2 inflammation status and nasal polyp burden - Summary - MDSpire

Real-world efficacy of stapokibart for severe olfactory dysfunction: early and sustained improvement independent of baseline type 2 inflammation status and nasal polyp burden

  • By

  • Xiang-Ning Cheng

  • Liu-Qing Zhou

  • Yue Zhou

  • Sha-Zhou Li

  • Shan Chen

  • Qing Cheng

  • Li-Yue Li

  • Jian-Jun Chen

  • Tao Zhou

  • June 11, 2026

  • 0 min

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Objective:

To evaluate the efficacy of stapokibart in CRSwNP patients with moderate-to-severe olfactory dysfunction and the impact of baseline characteristics on olfactory recovery.

Approach:
    Key Findings:
    • Stapokibart led to significant olfactory improvement by Week 2 (P<0.0001).
    • At Week 16, 52.5% of patients achieved normosmia.
    • Mean objective olfactory score increased from 3.05 ± 2.98 to 11.35 ± 3.73 (P<0.0001).
    • Nasal polyp score decreased from 4.03 ± 1.70 to 1.63 ± 1.61 (P<0.001).
    Interpretation:

    Higher baseline polyp burden correlated with faster early improvement but did not affect the final outcomes of olfactory recovery.

    Conclusion:

    Stapokibart effectively and rapidly improves olfactory function in CRSwNP patients with moderate-to-severe olfactory dysfunction.

Original Source(s)

Real-world efficacy of stapokibart for severe olfactory dysfunction: early and sustained improvement independent of baseline type 2 inflammation status and nasal polyp burden

  • by Xiang-Ning Cheng, Liu-Qing Zhou, Yue Zhou, Sha-Zhou Li, Shan Chen, Qing Cheng, Li-Yue Li, Jian-Jun Chen, Tao Zhou

  • June 11, 2026

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