Predicting Ordinal Clinical Outcomes in At-Risk Mental States: A Multimodal Approach - Summary - MDSpire

Predicting Ordinal Clinical Outcomes in At-Risk Mental States: A Multimodal Approach

  • By

  • Nagasawa, Kazuya

  • Higuchi, Yuko

  • Kaneko, Naohito

  • Miyazu, Kensei

  • Shimataki, Shunsuke

  • Nishiyama, Shimako

  • Akasaki, Yukiko

  • Izumi, Marino

  • Tsujii, Noa

  • Takahashi, Tsutomu

  • April 13, 2026

  • 0 min

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Objective:

To identify predictors of multilevel clinical outcomes in individuals with at-risk mental states (ARMS) using a multimodal framework.

Key Findings:
  • Reduced baseline dMMN amplitude is associated with worse ordered clinical outcomes.
  • Greater severity of attenuated positive symptoms, particularly unusual thought content, is linked to poorer outcomes.
  • Poor cognitive functioning related to daily living is independently associated with worse clinical outcomes.
Interpretation:

Limitations:
Conclusion:

Original Source(s)

Predicting Ordinal Clinical Outcomes in At-Risk Mental States: A Multimodal Approach

  • by Nagasawa, Kazuya , Higuchi, Yuko , Kaneko, Naohito , Miyazu, Kensei , Shimataki, Shunsuke , Nishiyama, Shimako , Akasaki, Yukiko , Izumi, Marino , Tsujii, Noa , Takahashi, Tsutomu

  • April 13, 2026

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