To elucidate the mechanisms by which microRNAs (miRNAs) modulate apoptosis, autophagy, myocardial fibrosis, inflammatory response, and energy metabolism in heart failure (HF).
Key Findings:
miRNAs mediate survival and death of myocardium, inhibiting excessive apoptosis and oxidative damage.
They inhibit pathological ventricular remodeling and fibrosis.
miRNAs control autophagy and energy metabolism of cardiac cells.
They suppress inflammatory responses and maintain calcium signaling homeostasis.
Interpretation:
MicroRNAs collectively influence the survival, remodeling, and energy balance of cardiac muscle cells in heart failure.
Limitations:
The clinical application of miRNAs in HF is still in early exploration.
The true diagnostic value and therapeutic potential of miRNAs need further confirmation through rigorous and large-scale clinical studies.
Conclusion:
MicroRNAs play a significant role in the pathophysiology of heart failure, but further research is required to establish their clinical utility.
