Objective:

To describe obstetric and perinatal outcomes of pregnant women with advanced maternal age (AMA) conceiving through in vitro fertilization (IVF) technology.

Approach:

• Study Design: A single-center prospective observational study conducted between January and December 2024, including women aged 40 and older who conceived via IVF.
• Participants: 128 pregnant women were included, with regular prenatal follow-up in a maternal-fetal unit.
• Subgroup Analysis: A subgroup analysis was conducted comparing women aged 40–44 years to those aged 45 years and older.

Key Findings:

• 46.88% of participants were primigravid (n = 60).
• 55.47% of pregnancies resulted from oocyte donation (n = 71).
• Obstetric complications included gestational diabetes (n = 3, 2.34%), hypertensive disorders (n = 6, 4.76%), preterm premature rupture of membranes (n = 11, 8.59%), preterm intrauterine growth restriction (n = 7, 5.56%), and preterm delivery (n = 15, 11.72%).
• Higher rates of PPROM, preterm IUGR, and preterm delivery were observed in women aged 45 or older.
• Cesarean delivery was performed in 62 cases (49.6%).
• Median birth weight was 3,028 g; 6.45% of newborns required ICU admission.

Interpretation:

The study provides descriptive clinical data regarding pregnancies in women of advanced maternal age following IVF.

Limitations:

• Single-center design limits generalizability.
• Lack of comparison groups and larger sample sizes.

Conclusion:

Further research is needed to clarify the contributions of AMA and IVF to obstetric and perinatal outcomes.