Objective:

To compare the prognostic predictive performance of the BLAST, BLAST-mol, CPSS, and CPSS-mol in Chinese patients with Chronic Myelomonocytic Leukemia (CMML).

Approach:

Key Findings:

• Severe anemia and TP53 mutation were identified as independent poor prognostic factors for overall survival (OS).
• The BLAST scoring system demonstrated superior risk stratification compared to CPSS, with significant differences in median OS across risk groups.
• The BLAST-mol model also showed significant differences in median OS across risk categories, outperforming CPSS-mol.

Interpretation:

Limitations:

• The study was conducted in a single ethnic group, which may limit generalizability.
• The sample size may not be sufficient to fully validate the prognostic models.

Conclusion:

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