Objective:

To compare the prognostic predictive performance of the BLAST, BLAST-mol, CPSS, and CPSS-mol in Chinese patients with Chronic Myelomonocytic Leukemia (CMML).

Approach:

Key Findings:

• Severe anemia and TP53 mutation were identified as independent poor prognostic factors for overall survival (OS).
• The BLAST scoring system demonstrated superior risk stratification compared to CPSS, with significant differences in median OS across risk groups.
• The BLAST-mol model also showed significant differences in median OS across risk categories, outperforming CPSS-mol.

Interpretation:

Limitations:

• The study was conducted in a single ethnic group, which may limit generalizability.
• The sample size may not be sufficient to fully validate the prognostic models. -

Conclusion:

Further studies with larger and more diverse populations are needed to validate these models and enhance their applicability. ---

Source

Based on findings from:

BLAST demonstrates higher prognostic accuracy for survival than CPSS in Chinese patients with chronic myelomonocytic leukemia

Xin Yan, Gege Feng, Zhimei Cai, Jiale Ma, Shuqian Xu, Zheng Ge. Blood Cancer Journal, 2026.

https://www.nature.com/articles/s41408-026-01536-5

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This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.