Objective:

To determine the proportion of patients initially diagnosed with cannabis-induced psychosis (CIP) who were later diagnosed with schizophrenia spectrum disorders (SSD) or bipolar disorder (BD), and to identify specific influencing variables such as demographic factors and substance use history.

Key Findings:

• Approximately 34% of patients with CIP are later diagnosed with SSD.
• Patients with CIP show a significant propensity to develop BD compared to matched controls, with specific rates to be detailed.
• The association between CIP and future SSD diagnoses is stronger than with other substances.

Interpretation:

The findings suggest a potential need for reclassification of CIP under SSD, highlighting the importance of long-term management strategies for affected patients and the implications for treatment guidelines.

Limitations:

• Variability in methodologies and reported variables across studies.
• Some studies included overlapping cohorts, potentially skewing results, which should be addressed in future research.
• Limited research specifically addressing the development of BD in CIP patients.

Conclusion:

The study underscores the necessity for updated treatment guidelines for CIP, considering its association with SSD and BD, and the implications for patient management.