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Impact of Maternal Thyroid Function During Pregnancy on Adolescent Brain Microstructure: Findings from the Controlled Antenatal Thyroid Screening Study III
To establish whether adolescent white matter microstructure is affected by suboptimal gestational thyroid function (SGTF), highlighting its potential implications for neurodevelopment.
Key Findings:
Untreated SGTF was associated with higher mean diffusivity in the inferior longitudinal fasciculus compared to normal GTF (P = .007), indicating reduced axonal integrity.
No significant differences in white matter microstructure were found between treated SGTF and normal GTF after corrections for multiple comparisons.
Interpretation:
Untreated SGTF may lead to altered white matter microstructure in adolescence, which could potentially be reversible with levothyroxine treatment during pregnancy.
Limitations:
Secondary and exploratory outcomes did not survive corrections for multiple comparisons, limiting their interpretability.
The limited sample size may affect the generalizability of findings, suggesting the need for larger studies.
Conclusion:
Maternal thyroid function during pregnancy has significant implications for adolescent brain microstructure, emphasizing the importance of monitoring and treating SGTF to potentially mitigate neurodevelopmental risks.
by Carolyn B McNabb, Anna Scholz, Laura Bloomfield, Raghav Bhargava, Charlotte Hales, Colin M Dayan, Sonya Foley, Peter N Taylor, John H Lazarus, Onyebuchi Okosieme, Marian Ludgate, Derek K Jones, D Aled Rees
Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.
