Case Report: Low-frequency tibial nerve stimulation: demonstrating a novel therapeutic option for Fowler’s syndrome through a pilot case series - Summary - MDSpire

Case Report: Low-frequency tibial nerve stimulation: demonstrating a novel therapeutic option for Fowler’s syndrome through a pilot case series

  • By

  • Aidan McConnell-Trevillion

  • Ingrid Hoeritzauer

  • Helen Simpson

  • Jalesh N. Panicker

  • Jon Stone

  • Dani Coombe

  • Kianoush Nazarpour

  • May 20, 2026

  • 0 min

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Objective:

To explore if low-frequency Transcutaneous Tibial Nerve Stimulation (TTNS) can improve symptoms of Fowler’s Syndrome.

Key Findings:
  • 50% of participants (N = 3) showed a positive response to TTNS, with a median increase in voiding efficiency from 6.3% to 12.6%.
  • Two participants exhibited a negative response, with a median decrease in voiding efficiency from -3.6% to -20.9%.
  • The study suggests TTNS may significantly improve symptoms in some cases of Fowler’s Syndrome, with a p-value of <0.05 indicating statistical significance.
Interpretation:

The findings indicate potential therapeutic benefits of low-frequency TTNS for patients with Fowler’s Syndrome, warranting further clinical investigation.

Limitations:
  • Small sample size (N = 6) limits generalizability.
  • Short duration of study with no follow-up assessments.
  • Lack of diversity in the participant sample may affect the applicability of results.
Conclusion:

TTNS shows promise as a non-invasive treatment for Fowler’s Syndrome, providing a foundation for future research, particularly larger studies to validate these findings.

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